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欧盟就β-1.4-内切木聚糖酶作为火鸡饲料添加剂发布意见

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核心提示: 据欧盟食品安全局(EFSA)消息,应欧盟委员会的要求,7月25日欧盟食品安全局就-1.4-内切木聚糖酶(endo-1,4-beta-xylanase)作为
     据欧盟食品安全局(EFSA)消息,应欧盟委员会的要求,7月25日欧盟食品安全局就β-1.4-内切木聚糖酶(endo-1,4-beta-xylanase)作为火鸡饲料添加剂发布了意见。

    此次β-1.4-内切木聚糖酶由非转基因康氏木霉产生,拟以75至100AXC/kg的剂量用于育肥火鸡以及种鸡。

    部分原文报道如下:

        Following a request from the European Commission, the Panel on AddITives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the additive Feedlyve AXC when used as a zootechnical additive in turkeys. This additive is a preparation of endo-1,4-beta-xylanase (EC 3.1.2.8) produced by a non-genetically modified strain of Trichoderma koningii (MUCL 39203). It is intended for use in turkeys for fattening and reared for breeding at a dose range of 75 to 100 AXC/kg feed.

    The additive is presented in several forms, and the solid and liquid forms of the product are considered to be equivalent in terms of safety for the target animals and efficacy.

    A tolerance study performed with a 100-fold of the maximum recommended dose, showed no adverse effects in turkeys for fattening. Therefore, the FEEDAP Panel concludes that Feedlyve AXC is safe for turkeys for fattening at the maximum recommended dose (100 AXC/kg feed). This conclusion is extended to turkeys reared for breeding.

    The results of two genotoxicity in vitro studies and a sub-chronic oral toxicity study did not indicate any concern for consumer safety arising from the use of the additive as a feed additive for turkeys.

    Feedlyve AXC 6000P was negative in dermal and eye irritation tests in the rabbit. No data on the skin/eye irritation potential of the BRUTE formulation is available. Therefore, the FEEDAP Panel considers it prudent to treat this formulation as a potential skin/eye irritant. No skin sensitization and no acute respiratory toxicity were observed in appropriate tests using the BRUTE formulation. Due to the proteinaceous nature of the compound the additive is to be considered as a potential respiratory sensitiser.

    The active substance of Feedlyve AXC is a protein and as such will be degraded/inactivated during the passage through the digestive tract of animals. Therefore, no risks for the environment are expected and no further environmental risk assessment is required.

    A total of three efficacy studies in turkeys for fattening were provided. Results showed that the additive has the potential to be efficacious in diets for turkeys for fattening at a minimum dose of 75 AXC/kg complete feed. This conclusion can be extended to turkeys reared for breeding.
 
    原文链接:<http://www.efsa.europa.eu/en/efsajournal/doc/2843.pdf>

 
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